Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome

Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome

The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help unde...

Animal Model of Interstitial Cystitis/Bladder Pain Syndrome

Bladder Pain Syndrome/Interstitial cystitis:

Background BPS/IC is a chronic syndrome with bladder pain, divided into two main types: one with so called Hunner`s lesions (classic type) and one without (nonulcer type). In the recently presented ESSIC classification system the classic type, in focus of the present work, has the designation Type 3C BPS/IC. Symptoms are characterized by bladder pain, urgency, frequency and nocturia. The aetiol...

Bladder Pain Syndrome/ Interstitial Cystitis

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Interstitial cystitis: a chronic pelvic pain syndrome.

Interstitial cystitis, an enigmatic chronic pelvic pain syndrome that occurs primarily in women, is much more common than originally believed. Its etiology is unknown, its evaluation and diagnosis remain controversial, and its treatment is largely empiric. Recent basic and clinical research is unlocking some of the mystery surrounding this clinical syndrome. Diagnostic awareness, willingness to...